Volume 5, Issue 1, March 2020, Page: 1-6
Seroprevalence of Herpes Simplex Virus Type 2 and HIV Co-Infection Among Pregnant Women in Jigawa State
Amoo Florence Kemi, Department of Microbiology and Biotechnology, Faculty of Science, Federal University, Dutse, Nigeria
Sani Nura Muhammad, Department of Microbiology and Biotechnology, Faculty of Science, Federal University, Dutse, Nigeria
Gumel Ahmad Muhammad, Department of Microbiology and Biotechnology, Faculty of Science, Federal University, Dutse, Nigeria
Eze Lovelyn Chinyere, Department of Microbiology and Biotechnology, Faculty of Science, Federal University, Dutse, Nigeria
Nafisat Baita, Department of Microbiology and Biotechnology, Faculty of Science, Federal University, Dutse, Nigeria
Mukhtar Sa’adatu Ismail, Department of Microbiology and Biotechnology, Faculty of Science, Federal University, Dutse, Nigeria
Dauda Hauwa Sani, Department of Microbiology and Biotechnology, Faculty of Science, Federal University, Dutse, Nigeria
Received: Dec. 11, 2019;       Accepted: Dec. 25, 2019;       Published: Jan. 8, 2020
DOI: 10.11648/j.ijmb.20200501.11      View  147      Downloads  80
Abstract
Herpes simplex virus type 2 (HSV-2) infections is one of the most common sexually transmitted infections Worldwide. It facilitates the acquisition of HIV and is the primary cause of genital herpes which when acquired by women during pregnancy account for half of the mobidity and mortality among neonates. Lifelong latent HSV-2 infection raises concern among women of reproductive age considering the risk of neonatal transmission. In Nigeria screening for HSV-2 and co-infection with HIV in antenatal clinics is not routinely done. A cross-sectional study, was carried out among pregnant women attending antenatal clinics in four hospitals in Jigawa state. A total of 300 consenting pregnant women were enrolled, the study involved collection of sociodemographic data and laboratory determination of HSV-2 immunoglobulin G (IgG) and HIV seroprevalence using WHO standard procedure of Enzyme Linked Immunosorbent Assay (ELISA) test kit (DIAPRO Diagnostic Bioprobes, Milano, Italy), UNI-GOLD Wicklow, Ireland and ALERE Determine, respectively. Statistical significance was determined at p<0.05Of the 300 samples tested, overall seroprevalence of 55 (18.3%) and 44 (14.7%) for HSV-2 and HIV were recorded. The HSV-2 and HIV Co-infection rate was 16 (5.3%) among respondent. About 87.5% of the co-infection occurred in respondents that were in their 2nd Trimester. Addionally, co-infection was found to be high among respondents between the age of 15-34yrs with 81.3%. In this study, education status, parity, stage of pregnancy, occupation, History of blood transfusion had no statistical significance with HSV-2 and HIV co-infection (p>0.05). This study has demonstrated the existence and risk of neonatal herpes in the study area. It is recommended that HSV testing should be placed among the standard medical checkup tests in the area, again advocacy and public awareness on the potential public health burden of HSV-2 and HIV co-infection should be observed.
Keywords
HIV, HSV-2, Virus, Co-infection, ELISA, STIs, Neonatal
To cite this article
Amoo Florence Kemi, Sani Nura Muhammad, Gumel Ahmad Muhammad, Eze Lovelyn Chinyere, Nafisat Baita, Mukhtar Sa’adatu Ismail, Dauda Hauwa Sani, Seroprevalence of Herpes Simplex Virus Type 2 and HIV Co-Infection Among Pregnant Women in Jigawa State, International Journal of Microbiology and Biotechnology. Vol. 5, No. 1, 2020, pp. 1-6. doi: 10.11648/j.ijmb.20200501.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Corley, L. (2009). Synergistic co pathogens: HIV and HSV-2. N. Engl J. Med. 356: 854-856. https://dx.doi.org/10.1056/nejm199708213370801.
[2]
Freeman, E., Weiss, H., Glynn, J., Cross, P. L., Withworth, J. A. and Hayes, R. J. (2006). Herpes simplex virus 2 infection increases HIV acquisition in men and women: Systematic review and meta-analysis of longitudinal studies, AIDS, 20: 73–83.
[3]
Bastien, S., Mason-Jones, A., De Koker, P., Mmbaga, E., Ross, D. and Mathews, C. (2016): Herpes simplex virus type-2 infection as a biomarker for sexual debut among young people in sub-Saharan Africa: a literature review. International journal STD AIDS. 23 (11): 761–766. https://www.ncbi.nlm.nih.gov/pubmed/23155093.
[4]
Kalu, E. I. (2014). Seroprevalence of Herpes simplex virus infection among pregnant Women in Benin. International journal of Tropical Diseases and Health, 4 (1) 70-81. https://www.sciencedomain.org.
[5]
Iche, K. E. (2014). Seroprevalence of herpes simplex virus infection among pregnant women attending Antenatal clinic in Benin, Nigeria. Int. J. Trop Dis Health. 4 (1): 70-81.
[6]
Cowan, F. M, Humphrey J. H, Ntozini, R., Mutasa, K., Morrow, R. and Iliff, P., (2015): Maternal herpes simplex virus type 2 infection, syphilis and risk of intra-partum transmission ofHIV-1: Results of a case control study. AIDS. 22: 193-201.
[7]
Chen, K. T., Segú, M., Lumey, L. H., Kuhn, L., Carter, R. J. and Bulterys, M. (2015): Genitalherpes simplex virus infection and perinatal transmission of human immunodeficiency virus. Obstet Gynecol. 106: 1341-8.
[8]
Looker, K. J., Magaret, A. S., Turner, K. M. and Newman, L. M. (2015): Global estimate of prevalent and incident herpes simplex virus type 2 infections. PLoS One 2013; 10: e114989.
[9]
Brown, Z. (2008). Preventing Herpes Simplex Virus Transmission to the Neonate. J. Infectious Disease 3; 175-186. https://dx.doi.org/10.1056/nejm.
[10]
Brown, Z. A., Wald, A., Morrow, R. A., Selke, S., Zeh, J. and Corey L. (2003). Effect of serologic status and cesarean delivery on transmission rates of herpes simplex virus from mother to infant. JAMA. 289 (2): 203- 209: https://reference.Medscape.com/medline.
[11]
Obijimi, O. T., Ajetomobi, A. B., Sule, W. P. and Olarewaju, D. O. (2013). Prevalence of herpes Simplex virus specific immunoglobulim-g and –m in pregnant women. South western Nigeria. Afr J clin Exp; 14: 134-139.
[12]
Mawak, J. D., Dashe, N., Agabi, Y. A. and Zakeri, H. (2012). Seroprevalence and co-infection of herpes simplex virus type2 and human immunodeficiency virus in Nigeria Shiraz E-Med J. 13 (1): 12-44.
[13]
Yusuf, M., Bolaji, N. and Herry, I. (2012). Prevalence of Herpes Simplex Virus among women in Nigeria. Journal of Virology, 80 (20), 9340-9348.
[14]
Nabi, S. N., Wasey, A., Haider, K. M., and Hoque, M. M. (2012). Seroprevalence of TORCH Antibody in pregnant women. J. A. F. M. C. 8: 35-39.
[15]
Idress, H. A. and Eihag, W. I. (2015). Seroprevalence of HSV-2 among pregnant women Attending Malik Teaching Hospital, Khartoum State, Sudan. American J. 3: (11) 149-160.
[16]
Otti, V. B., Usman, B. A., Pennap, G. R. and Eno-ibanga, C. K. (2017). Seroprevalence of Herpes simplex virus type-2 among pregnant women Accessing Antenatal care at Federal Medical Center, Keffi, Nigeria. Asian J. R. M & P. S. 1 (4): 1-6.
[17]
Anaedobe, C. G. and Ajani, T. A. (2019). Co-infection of herpes simplex virus type-2 and HIV Infections among pregnant women in Ibadan, Nigeria. Global Infectious Disease; 11: 19-24. http://www.jgid.org/text.asp 2019/11/1/19/251843.
[18]
Weiss, H. (2004). Epidemiolog1y of herpes simplex virus type -2 infection in the Developing World. Herpes11: 24A-35A.
[19]
Kolawole, O. M., Amuda, O. O., Suleiman, M. M., Nzurumike, C. and Ogah, J. I. (2016). Seroprevalence and Co-infection of HIV and HSV among pregnant women in Lokoja, North–Central Nigeria. Iranian RCM J. 18 (10): e25284.
[20]
Amah, O. A., Bajaj, H. K., Singla, A. and Masih, H. (2015). Prevalence of HSV in pregnant Women from Gangetic, India. Advance Microbiology. 5: 404-408.
[21]
Kolawole, O. M., Adu F. D., Agbede O. O. and Bakare R. A. (2008). Epidemiological patterns of HIV and HSV Co-infection in Ibadan, Nigeria. African Journal of Biomedical Research. 11: 23-26.
[22]
Ameh, E. R., Aminu, M. and Ella, E. E. (2016). Seroprevalence of HSV-2 among women of Reproductive Age in Zaria, Kaduna State, Nigeria. Biology Medicals 8: 338.
[23]
Celum, C., Levine, R., Weaver, M. and Wald, A. (2004). Genital herpes and human immunodeficiency virus: double trouble. Bull World Health Organ. 82 (6): 447-453. https://www.ncbi.nlm.nih.gov/pmc/articles/pmc2622854.
[24]
Suazo, P. A., Tognarelli, E. I., Kalergis, A. M. and González, P. A. (2015). Herpes simplex virus 2 infection: molecular association with HIV and novel microbicides to prevent disease. Medical Microbiological Immunology. 204 (2): 161-176. https://dx.doi.org./10.10077.
[25]
Chun, H. M., Carpenter R. J. and Macalino G. E. (2013). The Role of Sexually transmitted infections in HIV-1 progression: Review of the Literature Disease: 176459.
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